For 
                              those on aspartame support groups
                              who have had questions about the liver problems 
                              from aspartame,
                              and why some physicians question hepatitis in aspartame 
                              victims. 
                           
                           
                          From 
                            James Bowen, M.D.   June 4, 2001 
                          Steato 
                            Hepatitis, characterized by an accumulation of fat 
                            in the hepatocyte (liver cell) resulting from ingestion 
                            of aspartame is focused in the mitochondria. Mitochondria 
                            are the energy furnaces of the cell and aspartame 
                            (APM) metabolism into more toxic derivatives, formaldehyde 
                            and formic acid take place in the mitochondria. As 
                            in all NutraSweet poisoning the formaldehyde and formic 
                            acid immediately attack the tissues they are generated 
                            in so we see a new co-existent plague of "anti-mitrochondrial 
                            antibody hepatitis" generated right along with the 
                            steato hepatitis because the immune system reacts 
                            to the degenerated tissues.
                           
                            The breakdown of fats into energy producing chemicals 
                            has obligatory metabolism via mitochondrial mechanisms. 
                            When mitochondria are rendered defective by aspartame 
                            poisoning fat cannot be processed to be used for energy. 
                            The formation of fat from dietary calories proceeds 
                            because fat is built up directly in the cytosol of 
                            cells and accumulation is not dependent on mitochondrial 
                            function. So liver cells and fat cells and after fats 
                            cells (lipocytes) store fat and cannot get rid of 
                            it no matter how badly it is needed to supply energy 
                            to the body.
                          Thanks 
                            to NutraSweet these victims literally cannot starve 
                            the fat off of their bodies or out of their livers 
                            because of their compromised mitochondrial functional 
                            capacity. To make matters worse the mitochondrial 
                            DNA is severely damaged.
                          Methanol/formaldehyde 
                            poisoning occurring as the direct result of the obligatory 
                            metabolism of methyl radicals is the most common form 
                            of genetic damage, caused by formaldehyde cross linkage 
                            of DNA strains. The mitochondrial DNA is thousands 
                            of times more vulnerable to this than nuclear DNA, 
                            and lack the excellent repair mechanisms that protects 
                            the integrity of nuclear DNA. The presently understood 
                            mitochondria DNA repair mechanisms are merely excisional, 
                            that is the DNA rendered abnormal by the aspartame/methanol 
                            poisoning is merely excised leaving the mitochondrial 
                            function at best insufficient, defective and incomplete. 
                            Which in addition to producing inadequate and incomplete 
                            energy metabolism spins off highly damaging free radicals. 
                            Methanol/formaldehyde poisoning is noted for this.
                           
                            This vicious circle amounts to tremendous degenerative 
                            process in the human organism and the unfortunate 
                            results too numerous to be repeated here but are well 
                            detailed on dorway.com 
                            and other excellent sites such as holisticmed.com, 
                            as well as Dr. Hyman Roberts text on the subject. 
                            (Aspartame Disease: The Ignored Epidemic - 1 800 814 
                            - 9800 or www.sunsentpress.com 
                            ).
                          This 
                            amounts to virtual "genocide", and is further emphasized 
                            by the fact this mitochondrial DNA damage is directly 
                            transmitted by female NutraSweet users to her children 
                            and grandchildren, and to subsequent generations via 
                            her female descendents.