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Message - Important notice to Ribavirin users
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This information comes from the National Institute of Allergy and Infectious Disease
Ribavirin use poses two significant safty issues:
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- In animal species ribavirin is significantly teratogenic and /or embrocidal, i.e., an agent that can cause birth defects or kill embryos. Hence, males as well as females who take this drug
combination must practice effective contraception both during treatment and for 6 months afterwards. Females should have a negative pregnancy test before beginning therapy.
- Ribavirin is associated with a dose-dependent, reversible hemolytic anemia that in the combination study required dose reduction in 7%-10% of patients. Multiple laboratory and clinical evaluations
are needed over the coarse of treatment.
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